BHI Stem Cell Sources
Allogenic (genetically similar, but not identical) Stem Cells
Human Umbilical cord blood (hUCB)
- Rich source of hematopoietic stem and progenitor cells as well as non-hematopoietic stem cells such as: endothelial cells, mesenchymal stem cells (MSCs) and unrestricted somatic stem cells (USSC).
- Cells from UCB can be used directly after isolation without expansion.
- The human leukocyte antigen type (HLA) does not need a closely-matched-donor for non-hematopoetic purposes (growth factor production, immune modulation), because these cells are less likely to induce immunological reactions.
Wharton’s jelly (WJ)
- Expanded MSCs from WJ of healthy donors who underwent elective full-term pregnancy caesarean sections.
- Umbilical Cord is collected from primiparous pregnant women receiving caesarean section in accordance with the sterile procedure guidelines in each hospital.
Autologous (obtained from the same individual) Stem Cells
Adipose Tissue derived stem cell
- Adipose tissue can be easily obtained: almost without pain under local anesthesia; without risk of thrombosis or introduction of infection into the bone marrow resulting in sepsis or osteomyelitis.
- Stromal vascular fraction of adipose tissue contains mesenchymal stem cells that have the capacity to differentiate into cartilage, bone, muscle, and adipose tissue. Mesenchymal stem cells have been proposed as an optimal regenerative cellular therapeutic for musculoskeletal conditions like osteoarthritis and rheumatoid arthritis.