Traumatic Brain Injury
Traumatic brain injury (TBI), also known as intracranial injury, occurs when an external force traumatically injures the brain. TBI can be classified based on severity, mechanism (closed or penetrating head injury), or other features (e.g., occurring in a specific location or over a widespread area). Head injury usually refers to TBI, but is a broader category because it can involve damage to structures other than the brain, such as the scalp and skull.
TBI is a major cause of death and disability worldwide, especially in children and young adults. Causes include falls, vehicle accidents, and violence. Prevention measures include use of technology to protect those suffering from automobile accidents, such as seat belts and sports or motorcycle helmets, as well as efforts to reduce the number of automobile accidents, such as safety education programs and enforcement of traffic laws.
Brain trauma can be caused by a direct impact or by acceleration alone. In addition to the damage caused at the moment of injury, brain trauma causes secondary injury, a variety of events that take place in the minutes and days following the injury. These processes, which include alterations in cerebral blood flow and the pressure within the skull, contribute substantially to the damage from the initial injury.
TBI can cause a host of physical, cognitive, social, emotional, and behavioral effects, and outcome can range from complete recovery to permanent disability or death.
Stem cell therapy will be administered as an adjunct to standard of care for TBI patients. Subjects will have three sessions of 1x intravenous (IV) infusion and 1x intrathecal (IT) injection, spaced 5-12 days apart. Safety assessment will include administration of adverse events questionnaires, physical exam, and blood test conducted at specified intervals. Secondary outcome measure is efficacy. In order to assess efficacy of therapy, neuropsychological assessment, disability rating scale, Glasgow coma scale, SF-8 Health Survey and MRI will be conducted at specific intervals.
To find out more about how you may benefit from our stem cell research protocol, please complete our Contact Us form and one of our physicians will reach out to you for a private consultation.