BHI Stemcells

Exosomes by Blue Horizon

Our research

Our research has been published in esteemed journals, including Experimental and Therapeutic Medicine (cited at PubMed Central, US National Library of Medicine, NIH) and CellR4, the official journal of The Cure Alliance. Notably, we have conducted the only long-term safety study published in US peer-reviewed literature, with our index patient dating back to 2017 and showing no significant side effects.

Our Exosomes

The exosomes are derived from WJ-MSC medium. The team, led by Brian Mehling, M.D., oversees all aspects of the operation from informed consent of the donor to cord procurement, processing and culturing the cord, harvesting the exosomes/extracellular vesicles from the growth medium to the final harvest of the WJ-MSCs.

Our Process

Our exosomes, derived from WJ-MSC medium, are produced under the meticulous oversight of Brian Mehling, M.D., with a focus on high purity (>95%), scalability, and consistency across donors. Our exosomes are investigational and are characterized in the laboratory using established quality-control methods.

What are Exosomes

Exosomes are nanoscale extracellular vesicles, ranging in size from 30 to 150 nanometers, that are secreted by virtually all cell types. These vesicles originate from the endosomal compartment within cells and are released into the extracellular environment, where they serve as highly efficient mediators of intercellular communication. Exosomes carry a diverse cargo of bioactive molecules, including proteins, lipids, messenger RNA (mRNA), and microRNA (miRNA), which they deliver to recipient cells, where they are studied for their role in a variety of cellular processes. Researchers are investigating the part exosomes may play in immune signaling, cell-to-cell communication, and cellular biology. Their ability to transfer functional biomolecules across biological barriers has garnered significant interest in the scientific community, and exosomes are an active subject of ongoing research in regenerative medicine, oncology, and immunology.

Difference between
Stem Cells andExosomes

To learn more about the key differences between stem cells and exosomes, watch the insightful video explained by Dr. Brian Mehling. In this video, Dr. Mehling provides a detailed comparison, highlighting the unique properties and therapeutic potential of each, shedding light on their roles in modern medicine. Don’t miss out on this informative explanation!

BHI Exosome Sources

Human Umbilical Cord-Derived Exosomes (hUCB)

Human Umbilical cord blood (hUCB)

Rich in a variety of bioactive molecules, including proteins, lipids, and RNA, which are studied in regenerative medicine research.
Exosomes from human umbilical cord blood are studied as a source for non-hematopoietic research applications, in part due to their low immunogenicity.
These exosomes are also less likely to induce immune rejection, which is one reason they are of interest in research into allogeneic approaches.

Autologous (obtained from the same individual) Exosomes

Adipose-Derived Exosomes

Exosomes derived from adipose tissue are easily harvested with minimal discomfort under local anesthesia, offering a non-invasive source for exosome isolation.
Adipose tissue contains a rich variety of mesenchymal stem cells (MSCs) that produce exosomes, which are studied in regenerative medicine research.
Adipose-derived exosomes are an active subject of laboratory research, including studies relating to musculoskeletal biology and tissue function.
Adipose-derived exosomes are gaining interest in research into both aesthetic applications and regenerative medicine.

BHI Exosomes Quality And Research

We prioritize the highest standards of quality in the production of exosomes, focusing on purity and consistency. Sourced from well-characterized biological materials, such as human umbilical cord blood and adipose tissue, our exosomes undergo rigorous purification and quality control processes. Using advanced technologies like nanoparticle tracking analysis and electron microscopy, we verify their size and concentration. Our ongoing research is dedicated to studying exosomes in the field of regenerative medicine. As an organization committed to responsible scientific research, BHI conducts its work in accordance with applicable regulations.

BHI Exosomes Regulatory Compliance

At BHI, we are committed to maintaining high standards of quality and to conducting our work responsibly. Our exosome products are investigational and have not been approved by the U.S. Food and Drug Administration (FDA) or the European Medicines Agency (EMA). We strive to follow applicable regulations and industry best practices across our processes, from sourcing biological materials to exosome isolation, purification, and storage, with a focus on quality and traceability. Our exosomes are subject to laboratory testing intended to characterize their purity and to screen for contaminants.

We strive to conduct our research in accordance with ethical guidelines and applicable regulatory frameworks. BHI’s dedication to responsible practices reflects our commitment to transparency and integrity as we work to advance the field of regenerative medicine in a responsible and sustainable manner. Our exosome products are investigational, are not FDA-approved, and are not intended to diagnose, treat, cure, or prevent any disease.

Exosomes